SOME EFFECTS OF RADIUM RADIATIONS ON WHITE MICE
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SOME EFFECTS OF RADIUM RADIATIONS ON WHITE MICE. 



BY KANEMATSUSUGIURAANDGIOACCHINOFAILLA.

(From the Harriman Research Laboratory, The Roosevelt Hospital, and Memorial 

Hospital, New York.)


(Received for publication, December 23, 1921.)



It is well known that radium rays, as well as x-rays, are capable of 

affecting the living cell. Bergoni~ and Tribondeau1 from extensive 


experimental studies made the generalization2,3 that: "Immature cells 

and cells in an active state of division are more sensitive to the x-rays 

than are cells which have already acquired their fixed adult, morpho- 

logical or physiological characters. ''2 Subsequent observations have 


resulted in the extension of this generalization to the effect of radium 

radiations as well. For this reason the mice of the experiments de- 

scribed in the present paper were exposed to radium rays soon after 

birth and during the period of rapid growth.




Experimental.


The body weight of mice at birth and their subsequent rate of growth 


are influenced by many factors. It is essential, therefore, that con- 

trol experiments be carried out with animals as nearly as possible like 
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those treated; and that external conditions be identical for both groups r
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during the period of observation. The age, physical condition, and s
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body weight of the mother, the length of the gestation period, the l
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size of the litter, and its position in the litter series affect the inital b
l-
weight of mice and their growth. Accordingly, a litter of young was y
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divided into two nearly equal groups of both sexes; one to be exposed no
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to radiation and the other to be used as control. The method devisedh
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t Bergonit, J., and Tribondeau, L., Compt. rend. Acad., 1906, cxliii, 983.s
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2Colwell, H. A., and Russ, S., Radium, x-rays, and the living cell, London a
f
1915, 253.n
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a B@l&re, M., Cottentot, P., and Laborde, S., Radiologie and radiumtherapic, /

Paris. 1921, 223.p:
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